Science Immunology
- Volume 7
- Issue 74
- Aug 2022
ONLINE COVER Exclusion of CD45 from a CAR-T Synapse. This month’s cover features a confocal microscopy image in which a human T cell expressing a CD19-targeting chimeric antigen receptor (CAR), stained in red, has formed an immunological synapse with a human Raji B cell lymphoma cell (blue). CD45 (green), a bulky tyrosine phosphatase enzyme that can inhibit CAR-T activation, is effectively excluded from the central portion of this synapse. Xiao et al. developed a size-exclusion model to explain how the relative sizes of the CAR construct and the CD45 isoform on a CAR-T cell and the target antigen on a tumor cell calibrate CD45’s dampening of antigen-triggered CAR-T activation at the synapse.
Credit: Xiaolei Su/Yale UniversityResearch ArticlesBy
- Cristina C. Clement
- Jaspreet Osan
- et al.
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes
Research ArticlesBy
- Gloria Delfanti
- Filippo Cortesi
- et al.
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells
EditorialBy
- Eric J. Topol
- Akiko Iwasaki
Operation Nasal Vaccine—Lightning speed to counter COVID-19
Research ArticlesBy
- Anna Purcarea
- Sebastian Jarosch
- et al.
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity
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Science Immunology publishes original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques.
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