ONLINE COVER Closeup of FIND-IT barley. Global demand for food is driving improved agricultural productivity. Knudsen et al. demonstrate FIND-IT, an approach to rapidly develop resilient crop plants and improve microbial production systems. The method allows for selection and incorporation of domestication traits into the approximately 7000 undomesticated or semidomesticated crop plants that have superior drought tolerance, water tolerance, disease resistance and mineral use efficiency. Using cereal crop barley, the researchers show that FIND-IT can potentially serve as tool to help meet future food demands.